Open AccessNutrient Competition: A New Axis of Tumor Immunosuppression
Author(s) -
Madhusudhanan Sukumar,
Rahul Roychoudhuri,
Nicholas P. Restifo
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.08.064
Subject(s) - biology , immunosuppression , competition (biology) , immunology , ecology
It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation. Papers by Chang et al. and Ho et al. show that Warburg metabolism enables tumor cells to restrict glucose availability to T cells, suppressing anti-tumor immunity.
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