Open AccessSingle-Cell Analysis: The Differences That Kill
Author(s) -
Savaş Tay
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.08.053
Subject(s) - biology , virulence , cell , pathogen , population , macrophage , rna , single cell analysis , interferon , salmonella , microbiology and biotechnology , virology , genetics , gene , bacteria , demography , sociology , in vitro
Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.
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