Open AccessA Long-Distance Chromatin Affair
Author(s) -
Annette Denker,
Wouter de Laat
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.08.022
Subject(s) - biology , chromatin , chia pet , genetics , transcription factor , computational biology , human genome , evolutionary biology , genome , concordance , dna , gene , chromatin remodeling
Changes in transcription factor binding sequences result in correlated changes in chromatin composition locally and at sites hundreds of kilobases away. New studies demonstrate that this concordance is mediated via spatial chromatin interactions that constitute regulatory modules of the human genome.
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