Architectural and Functional Commonalities between Enhancers and Promoters | Zendy

Tae-Kyung Kim | Zendy; Ramin Shiekhattar | Zendy

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Architectural and Functional Commonalities between Enhancers and Promoters

Author(s) -

Tae-Kyung Kim,

Ramin Shiekhattar

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.08.008

Subject(s) - biology , promoter , enhancer , computational biology , evolutionary biology , genetics , gene , transcription factor , gene expression

With the explosion of genome-wide studies of regulated transcription, it has become clear that traditional definitions of enhancers and promoters need to be revisited. These control elements can now be characterized in terms of their local and regional architecture, their regulatory components, including histone modifications and associated binding factors, and their functional contribution to transcription. This Review discusses unifying themes between promoters and enhancers in transcriptional regulatory mechanisms.

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