A CTCF Code for 3D Genome Architecture | Zendy

Michael H. Nichols | Zendy; Victor G. Corces | Zendy

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A CTCF Code for 3D Genome Architecture

Author(s) -

Michael H. Nichols,

Victor G. Corces

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.07.053

Subject(s) - ctcf , biology , genome , computational biology , genetics , decoding methods , code (set theory) , dna , orientation (vector space) , architecture , evolutionary biology , computer science , gene , programming language , transcription factor , algorithm , geometry , mathematics , enhancer , set (abstract data type) , art , visual arts

The architectural protein CTCF plays a complex role in decoding the functional output of the genome. Guo et al. now show that the orientation of a CTCF site restricts its choice of interacting partner, thus creating a code that predicts the three-dimensional organization of the genome. We propose a DNA extrusion model to account for orientation-specific loop formation.

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