Open AccessLighting Up Genes in Single Cells at Scale
Author(s) -
Zhe Liu
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.07.052
Subject(s) - biology , genome , computational biology , scopus , genomics , chromatin , gene , genetics , medline , biochemistry
In this issue, Shachar et al. report a high-throughput imaging position mapping platform (HIPmap) enabling large-scale, high-resolution localization of 3D gene positions in single cells. Coupling loss-of-function screens with HIPmap, the authors identify DNA replication rather than mitosis as a major determinant of genome positioning.
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