SnapShot: Spliceosome Dynamics III | Zendy

M.C. Wahl | Zendy; Reinhard Lührmann | Zendy

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SnapShot: Spliceosome Dynamics III

Author(s) -

M.C. Wahl,

Reinhard Lührmann

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.07.033

Subject(s) - spliceosome , biology , rna splicing , genetics , computational biology , precursor mrna , alternative splicing , microbiology and biotechnology , exon , rna , gene

The complex compositional and conformational dynamics of spliceosomes required for regulated splicing are prone to malfunction when mutations affect splicing factors or cis-acting regulatory sequences. Indeed, many such mutations have been linked to heritable diseases or malignancies in humans. Small molecule modulators and antisense oligonucleotides or analogs harbor great potential for therapies and several substances that can modulate splicing events have entered clinical trials.

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