A Call for Systematic Research on Solute Carriers | Zendy

Adrián CésarRazquin | Zendy; Berend Snijder | Zendy; Tristan FrappierBrinton | Zendy; Ruth Isserlin | Zendy; Gergely Gyimesi | Zendy; Xiaoyun Bai | Zendy; R.A. Reithmeier | Zendy; David Hepworth | Zendy; Matthias A. Hediger | Zendy; A.M. Edwards | Zendy; Giulio SupertiFurga | Zendy

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A Call for Systematic Research on Solute Carriers

Author(s) -

Adrián CésarRazquin,

Berend Snijder,

Tristan FrappierBrinton,

Ruth Isserlin,

Gergely Gyimesi,

Xiaoyun Bai,

R.A. Reithmeier,

David Hepworth,

Matthias A. Hediger,

A.M. Edwards,

Giulio SupertiFurga

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.07.022

Subject(s) - biology , computational biology

Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of similar stature, SLCs are relatively understudied. The time is right for a systematic attack on SLC structure, specificity, and function, taking into account kinship and expression, as well as the dependencies that arise from the common metabolic space.

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