Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus | Zendy

Kristian G. Andersen | Zendy; B. Jesse Shapiro | Zendy; Christian B. Matranga | Zendy; Rachel Sealfon | Zendy; Aaron E. Lin | Zendy; Lina Moses | Zendy; Onikepe Folarin | Zendy; Augustine Goba | Zendy; Ikponmwonsa Odia | Zendy; Philomena E. Ehiane | Zendy; Mambu Momoh | Zendy; Eleina England | Zendy; S Winnicki | Zendy; Luis M. Branco | Zendy; Stephen Gire | Zendy; Eric Phelan | Zendy; Ridhi Tariyal | Zendy; Ryan Tewhey | Zendy; Omowunmi Omoniwa | Zendy; Mohammed Fullah | Zendy; Richard Fonnie | Zendy; Mbalu Fonnie | Zendy; Lansana Kanneh | Zendy; Simbirie Jalloh | Zendy; Michael Gbakie | Zendy; Sidiki Saffa | Zendy; Kandeh Karbo | Zendy; Adrianne D. Gladden | Zendy; James Qu | Zendy; Matthew Stremlau | Zendy; Mahan Nekoui | Zendy; Hilary K. Finucane | Zendy; Shervin Tabrizi | Zendy; Joseph J. Vitti | Zendy; Bruce Birren | Zendy; Michael G. FitzGerald | Zendy; Caryn McCowan | Zendy; Andrea Ireland | Zendy; Aaron M. Berlin | Zendy; James Bochicchio | Zendy; Bárbara TazónVega | Zendy; Niall J. Len | Zendy; Elizabeth M. Ryan | Zendy; Zach B. Bjornson | Zendy; Danny A. Milner | Zendy; Amanda K. Lukens | Zendy; Nisha Broodie | Zendy; Megan M. Rowland | Zendy; Megan L. Heinrich | Zendy; Marjan Akdag | Zendy; John S. Schieffelin | Zendy; Danielle Levy | Zendy; Henry Akpan | Zendy; Daniel G. Bausch | Zendy; Kathleen Rubins | Zendy; Joseph B. McCormick | Zendy; Eric S. Lander | Zendy; Stephan Günther | Zendy; Lisa E. Hensley | Zendy; Sylvanus Okogbenin | Zendy; S. F. Schaffner | Zendy; Peter O. Okokhere | Zendy; Sheik Humarr Khan | Zendy; Donald S. Grant | Zendy; George O. Akpede | Zendy; Danny Asogun | Zendy; Andreas Gnirke | Zendy; Joshua Z. Levin | Zendy; Christian T. Happi | Zendy; Robert F. Garry | Zendy; Pardis C. Sabeti | Zendy

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Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus

Author(s) -

Kristian G. Andersen,

B. Jesse Shapiro,

Christian B. Matranga,

Rachel Sealfon,

Aaron E. Lin,

Lina Moses,

Onikepe Folarin,

Augustine Goba,

Ikponmwonsa Odia,

Philomena E. Ehiane,

Mambu Momoh,

Eleina England,

S Winnicki,

Luis M. Branco,

Stephen Gire,

Eric Phelan,

Ridhi Tariyal,

Ryan Tewhey,

Omowunmi Omoniwa,

Mohammed Fullah,

Richard Fonnie,

Mbalu Fonnie,

Lansana Kanneh,

Simbirie Jalloh,

Michael Gbakie,

Sidiki Saffa,

Kandeh Karbo,

Adrianne D. Gladden,

James Qu,

Matthew Stremlau,

Mahan Nekoui,

Hilary K. Finucane,

Shervin Tabrizi,

Joseph J. Vitti,

Bruce Birren,

Michael G. FitzGerald,

Caryn McCowan,

Andrea Ireland,

Aaron M. Berlin,

James Bochicchio,

Bárbara TazónVega,

Niall J. Len,

Elizabeth M. Ryan,

Zach B. Bjornson,

Danny A. Milner,

Amanda K. Lukens,

Nisha Broodie,

Megan M. Rowland,

Megan L. Heinrich,

Marjan Akdag,

John S. Schieffelin,

Danielle Levy,

Henry Akpan,

Daniel G. Bausch,

Kathleen Rubins,

Joseph B. McCormick,

Eric S. Lander,

Stephan Günther,

Lisa E. Hensley,

Sylvanus Okogbenin,

S. F. Schaffner,

Peter O. Okokhere,

Sheik Humarr Khan,

Donald S. Grant,

George O. Akpede,

Danny Asogun,

Andreas Gnirke,

Joshua Z. Levin,

Christian T. Happi,

Robert F. Garry,

Pardis C. Sabeti

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.07.020

Subject(s) - lassa virus , biology , lassa fever , virology , ebola virus , ebolavirus , case fatality rate , virus , genome , genetics , gene , population , environmental health , medicine

The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reservoir samples. We show that whereas the 2013-2015 EVD epidemic is fueled by human-to-human transmissions, LASV infections mainly result from reservoir-to-human infections. We elucidated the spread of LASV across West Africa and show that this migration was accompanied by changes in LASV genome abundance, fatality rates, codon adaptation, and translational efficiency. By investigating intrahost evolution, we found that mutations accumulate in epitopes of viral surface proteins, suggesting selection for immune escape. This catalog will serve as a foundation for the development of vaccines and diagnostics. VIDEO ABSTRACT.

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