SnapShot: Spliceosome Dynamics II | Zendy

M.C. Wahl | Zendy; Reinhard Lührmann | Zendy

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SnapShot: Spliceosome Dynamics II

Author(s) -

M.C. Wahl,

Reinhard Lührmann

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.06.061

Subject(s) - spliceosome , biology , rna splicing , intron , minor spliceosome , polypyrimidine tract , genetics , computational biology , alternative splicing , gene , precursor mrna , splicing factor , microbiology and biotechnology , rna , exon

Numerous mechanisms exploit or modulate the conformational/compositional dynamics of spliceosomes to regulate splicing. The majority of higher eukaryotic protein-coding genes contain more than one intron and the derived pre-mRNAs can be alternatively spliced. Diverse principles ensure the reliable identification of authentic splice sites while concomitantly providing flexibility in splice site choice during alternative splicing. Some species contain a second type of minor (U12-type) spliceosome.

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