From Prescription to Transcription: Genome Sequence as Drug Target | Zendy

Cong Guo | Zendy; Anthony D’Ippolito | Zendy; Timothy E. Reddy | Zendy

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From Prescription to Transcription: Genome Sequence as Drug Target

Author(s) -

Cong Guo,

Anthony D’Ippolito,

Timothy E. Reddy

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.06.033

Subject(s) - biology , rosiglitazone , drug , type 2 diabetes , nuclear receptor , genetics , heritability , computational biology , transcription factor , bioinformatics , genome wide association study , pharmacology , diabetes mellitus , receptor , gene , endocrinology , genotype , single nucleotide polymorphism

Personalizing treatments to account for genetically mediated differences in drug responses is an exciting opportunity to improve patient outcomes. In this issue, Soccio et al. reveal new mechanisms by which non-coding variants alter the activity of the anti-diabetic drug rosiglitazone.

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