SnapShot: Growing Organoids from Stem Cells | Zendy

Toshiro Sato | Zendy; Hans Clevers | Zendy

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SnapShot: Growing Organoids from Stem Cells

Author(s) -

Toshiro Sato,

Hans Clevers

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.06.028

Subject(s) - organoid , biology , stem cell , induced pluripotent stem cell , microbiology and biotechnology , stem cell niche , pancreas , adult stem cell , cellular differentiation , progenitor cell , embryonic stem cell , genetics , biochemistry , gene

Tissue stem cells require unique niche microenvironments. In the presence of specific combinations of niche factors, mouse and human epithelial tissues from stomach, small intestine, colon, pancreas duct, and liver bile duct efficiently form stereotypic organoids. The platform of epitheloid organoids can also be employed for in vitro generation of digestive tissue from human pluripotent stem cells. Organoids hold great promise for basic and translational research.

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