Open AccessA Shortcut to Activity-Dependent Transcription
Author(s) -
Nikhil Sharma,
Harrison W. Gabel,
Michael E. Greenberg
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.06.009
Subject(s) - biology , transcription (linguistics) , transcription factor , computational biology , genetics , microbiology and biotechnology , gene , philosophy , linguistics
Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.
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