Open AccessWnt Down, Tumors Wind Up?
Author(s) -
Paul Krimpenfort,
Anton Berns
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.06.008
Subject(s) - biology , wnt signaling pathway , kras , cancer research , function (biology) , genetics , colorectal cancer , cancer , gene
In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an exquisite target for intervention.
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