Open AccessER Stress in Dendritic Cells Promotes Cancer
Author(s) -
Christopher Garris,
Mikaël J. Pittet
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.06.006
Subject(s) - xbp1 , biology , unfolded protein response , cancer , cancer research , dendritic cell , cancer cell , immunity , microbiology and biotechnology , immune system , immunology , gene , endoplasmic reticulum , genetics , rna , rna splicing
XBP1 is part of the ER stress response, and when activated in cancer cells, it fosters tumor growth. In this issue of Cell, Cubillos-Ruiz et al. demonstrate that XBP1 in tumor-infiltrating dendritic cells blunts anti-tumor immunity. These findings further imply XBP1 as a relevant target for cancer therapy.
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