Linking Micronuclei to Chromosome Fragmentation | Zendy

Emily M. Hatch | Zendy; Martin W. Hetzer | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Linking Micronuclei to Chromosome Fragmentation

Author(s) -

Emily M. Hatch,

Martin W. Hetzer

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.06.005

Subject(s) - chromothripsis , biology , genetics , chromosomal translocation , chromosome , chromosomal rearrangement , karyotype , genome instability , gene , dna , dna damage

Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research