SnapShot: Spliceosome Dynamics I | Zendy

M.C. Wahl | Zendy; Reinhard Lührmann | Zendy

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SnapShot: Spliceosome Dynamics I

Author(s) -

M.C. Wahl,

Reinhard Lührmann

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.05.050

Subject(s) - biology , spliceosome , rna splicing , intron , exon , computational biology , genetics , rna , precursor mrna , microbiology and biotechnology , messenger rna , minor spliceosome , gene

Spliceosomes are multi-megadalton RNA-protein molecular machines that carry out pre-mRNA splicing, that is, the removal of non-coding intervening sequences (introns) from eukaryotic pre-mRNAs and the ligation of neighboring coding regions (exons) to produce mature mRNA for protein biosynthesis on the ribosome. They are the prototypes of dynamic molecular machines, assembling de novo for each splicing event by the stepwise recruitment of subunits on a substrate.

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