Open AccessEmbryonic Origin of Postnatal Neural Stem Cells
Author(s) -
Luis C. Fuentealba,
Santiago B. Rompani,
Jose I. Parraguez,
Kirsten Obernier,
Ricardo Romero,
Constance L. Cepko,
Arturo Álvarez-Buylla
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.05.041
Subject(s) - biology , embryonic stem cell , progenitor cell , olfactory bulb , forebrain , microbiology and biotechnology , stem cell , neurosphere , neural stem cell , neuroepithelial cell , neuroscience , adult stem cell , neurogenesis , anatomy , central nervous system , genetics , gene
Adult neural stem/progenitor (B1) cells within the walls of the lateral ventricles generate different types of neurons for the olfactory bulb (OB). The location of B1 cells determines the types of OB neurons they generate. Here we show that the majority of mouse B1 cell precursors are produced between embryonic days (E) 13.5 and 15.5 and remain largely quiescent until they become reactivated postnatally. Using a retroviral library carrying over 100,000 genetic tags, we found that B1 cells share a common progenitor with embryonic cells of the cortex, striatum, and septum, but this lineage relationship is lost before E15.5. The regional specification of B1 cells is evident as early as E11.5 and is spatially linked to the production of neurons that populate different areas of the forebrain. This study reveals an early embryonic regional specification of postnatal neural stem cells and the lineage relationship between them and embryonic progenitor cells.
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