A CRISPR Connection between Chromatin Topology and Genetic Disorders | Zendy

Bing Ren | Zendy; Jesse R. Dixon | Zendy

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A CRISPR Connection between Chromatin Topology and Genetic Disorders

Author(s) -

Bing Ren,

Jesse R. Dixon

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.04.047

Subject(s) - biology , crispr , chromatin , connection (principal bundle) , computational biology , genetics , evolutionary biology , topology (electrical circuits) , dna , gene , combinatorics , engineering , mathematics , structural engineering

Structural variations are common in the human genome, but their contributions to human diseases have been hard to define. Lupiáñez et al. demonstrate that some structural variants can interrupt chromatin topology, resulting in ectopic enhancer-promoter interactions, altered spatiotemporal gene expression patterns, and developmental disorders.

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