Alike but Different: RAF Paralogs and Their Signaling Outputs | Zendy

Enrico Desideri | Zendy; Anna Lina Cavallo | Zendy; Manuela Baccarini | Zendy

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Alike but Different: RAF Paralogs and Their Signaling Outputs

Author(s) -

Enrico Desideri,

Anna Lina Cavallo,

Manuela Baccarini

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.04.045

Subject(s) - biology , mapk/erk pathway , microbiology and biotechnology , effector , phosphorylation , kinase , multicellular organism , signal transduction , carcinogenesis , conserved sequence , genetics , gene , peptide sequence

RAF links RAS, one of the most potent human oncogenes, to its effector ERK and to proliferation. This role is evolutionarily conserved, but while simpler multicellular organisms express one RAF, mammals have three. This Minireview highlights common and divergent features of RAF paralogs, their signaling outputs, and roles in tumorigenesis.

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