SnapShot: Insulin/IGF1 Signaling | Zendy

David Ma | Zendy; Christian Stolte | Zendy; James R. Krycer | Zendy; David E. James | Zendy; Séan O’Donoghue | Zendy

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SnapShot: Insulin/IGF1 Signaling

Author(s) -

David Ma,

Christian Stolte,

James R. Krycer,

David E. James,

Séan O’Donoghue

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.04.041

Subject(s) - biology , snapshot (computer storage) , signal transduction , microbiology and biotechnology , phosphorylation , transcription factor , insulin , insulin receptor , apoptosis , glucose homeostasis , homeostasis , transcription (linguistics) , energy homeostasis , cell cycle , bioinformatics , computational biology , genetics , receptor , insulin resistance , endocrinology , gene , philosophy , computer science , operating system , linguistics

The insulin/IGF1signaling pathway (ISP) plays an essential role in long-term health. Some perturbations in this pathway are associated with diseases such as type 2 diabetes; other perturbations extend lifespan in worms, flies, and mice. The ISP regulates many biological processes, including energy storage, apoptosis, transcription, and cellular homeostasis. Such regulation involves precise rewiring of temporal events in protein phosphorylation networks. For an animated version of this Enhanced SnapShot, please visit http://www.cell.com/cell/enhanced/odonoghue.

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