Open AccessAn Adenine Code for DNA: A Second Life for N6-Methyladenine
Author(s) -
Holger Heyn,
Manel Esteller
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.04.021
Subject(s) - biology , dna , epigenetics , gene , genetics , function (biology) , bacteria , genetic code , microbiology and biotechnology
DNA N6-methyladenine (6mA) protects against restriction enzymes in bacteria. However, isolated reports have suggested additional activities and its presence in other organisms, such as unicellular eukaryotes. New data now find that 6mA may have a gene regulatory function in green alga, worm, and fly, suggesting m6A as a potential "epigenetic" mark.
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