ALT Telomeres Get Together with Nuclear Receptors | Zendy

Eric Aeby | Zendy; Joachim Lingner | Zendy

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ALT Telomeres Get Together with Nuclear Receptors

Author(s) -

Eric Aeby,

Joachim Lingner

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.02.006

Subject(s) - telomere , biology , telomerase , homologous recombination , chromatin , genetics , chromosome , homologous chromosome , receptor , recombination , microbiology and biotechnology , nuclear receptor , dna , gene , transcription factor

Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI).

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