SnapShot: Genetics of ALS and FTD | Zendy

Rita Guerreiro | Zendy; José Brás | Zendy; John Hardy | Zendy

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SnapShot: Genetics of ALS and FTD

Author(s) -

Rita Guerreiro,

José Brás,

John Hardy

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.01.052

Subject(s) - amyotrophic lateral sclerosis , frontotemporal dementia , biology , snapshot (computer storage) , c9orf72 , neuroscience , dementia , tardbp , genetics , disease , pathology , medicine , computer science , operating system

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are considered to be part of a spectrum. Clinically, FTD patients present with dementia frequently characterized by behavioral and speech problems. ALS patients exhibit alterations of voluntary movements caused by degeneration of motor neurons. Both syndromes can be present within the same family or even in the same person. The genetic findings for both diseases also support the existence of a continuum, with mutations in the same genes being found in patients with FTD, ALS, or FTD/ALS.

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