Open AccessThe Metabolic Milieu of Metastases
Author(s) -
William J. Sullivan,
Heather R. Christofk
Publication year - 2015
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2015.01.023
Subject(s) - biology , phosphocreatine , extracellular , hypoxia (environmental) , kinase , colorectal cancer , creatine kinase , cancer research , creatine , microbiology and biotechnology , cancer , medicine , energy metabolism , biochemistry , endocrinology , genetics , chemistry , organic chemistry , oxygen
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
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