Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease | Zendy

Jason Norman | Zendy; Scott A. Handley | Zendy; Megan T. Baldridge | Zendy; Lindsay Droit | Zendy; Catherine Y. Liu | Zendy; Brian C. Keller | Zendy; Amal Kambal | Zendy; Cynthia L. Monaco | Zendy; Guoyan Zhao | Zendy; Phillip Fleshner | Zendy; Thaddeus S. Stappenbeck | Zendy; Dermot McGovern | Zendy; Ali Keshavarzian | Zendy; Ece Mutlu | Zendy; Jenny Sauk | Zendy; Dirk Gevers | Zendy; Ramnik J. Xavier | Zendy; David Wang | Zendy; Miles Parkes | Zendy; Herbert W. Virgin | Zendy

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Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

Author(s) -

Jason Norman,

Scott A. Handley,

Megan T. Baldridge,

Lindsay Droit,

Catherine Y. Liu,

Brian C. Keller,

Amal Kambal,

Cynthia L. Monaco,

Guoyan Zhao,

Phillip Fleshner,

Thaddeus S. Stappenbeck,

Dermot McGovern,

Ali Keshavarzian,

Ece Mutlu,

Jenny Sauk,

Dirk Gevers,

Ramnik J. Xavier,

David Wang,

Miles Parkes,

Herbert W. Virgin

Publication year - 2015

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2015.01.002

Subject(s) - human virome , biology , disease , inflammatory bowel disease , immunology , enteric virus , microbiology and biotechnology , genetics , pathology , metagenomics , gene , medicine

Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.

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