Open AccessAcetate Fuels the Cancer Engine
Author(s) -
Costas A. Lyssiotis,
Lewis C. Cantley
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.12.009
Subject(s) - glutamine , biology , cancer cell , warburg effect , cancer , metabolic pathway , metabolism , biochemistry , cell growth , histone , biosynthesis , tumor microenvironment , enzyme , amino acid , gene , genetics
Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and histone modification.
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