Open AccessSnapShot: GPCR-Ligand Interactions
Author(s) -
Eshan Ghosh,
Kumari Nidhi,
Arun K. Shukla
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.12.008
Subject(s) - biology , g protein coupled receptor , snapshot (computer storage) , receptor , microbiology and biotechnology , biophysics , ligand (biochemistry) , plasma protein binding , computational biology , biochemistry , computer science , operating system
G-protein-coupled receptors enable cells to recognize numerous external stimuli and to transmit corresponding signals across the plasma membrane to trigger appropriate cellular responses. Crystal structures of a number of these receptors have now been determined in inactive and active conformations bound to chemically and functionally distinct ligands. These crystal structures illustrate overall receptor organization and atomic details of ligand-receptor interactions
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