Open AccessSuper-Enhancer Transcription Converges on AID
Author(s) -
Jukka Alinikula,
David G. Schatz
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.12.007
Subject(s) - biology , enhancer , transcription (linguistics) , computational biology , transcription factor , genetics , microbiology and biotechnology , gene , linguistics , philosophy
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.
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