A Split Personality for Nucleosomes | Zendy

Daniel J. McKay | Zendy; Jason D. Lieb | Zendy

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A Split Personality for Nucleosomes

Author(s) -

Daniel J. McKay,

Jason D. Lieb

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.11.030

Subject(s) - nucleosome , biology , histone , linker dna , dna , computational biology , genetics , histone code , modular design , microbiology and biotechnology , transcription (linguistics) , chromatosome , biophysics , computer science , linguistics , philosophy , operating system

A high-resolution look at where histones touch DNA reveals a surprisingly intricate, dynamic, and modular nucleosome. Three advances in the study by Rhee et al. include unexpected interactions between the H3 tail and linker DNA, new evidence for existence of subnucleosomal particles, and asymmetric patterns of histone modification within a single nucleosome that correspond to the direction of transcription.

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