Species-wide Genetic Incompatibility Analysis Identifies Immune Genes as Hot Spots of Deleterious Epistasis | Zendy

Eunyoung Chae | Zendy; Kirsten Bomblies | Zendy; SangTae Kim | Zendy; Darya Karelina | Zendy; Maricris Zaidem | Zendy; Stephan Ossowski | Zendy; Carmen MartínPizarro | Zendy; Roosa A. E. Laitinen | Zendy; Beth A. Rowan | Zendy; Hezi Tenenboim | Zendy; Sarah Lechner | Zendy; Monika Demar | Zendy; Anette HabringMüller | Zendy; Christa Lanz | Zendy; Gunnar Rätsch | Zendy; Detlef Weigel | Zendy

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Species-wide Genetic Incompatibility Analysis Identifies Immune Genes as Hot Spots of Deleterious Epistasis

Author(s) -

Eunyoung Chae,

Kirsten Bomblies,

SangTae Kim,

Darya Karelina,

Maricris Zaidem,

Stephan Ossowski,

Carmen MartínPizarro,

Roosa A. E. Laitinen,

Beth A. Rowan,

Hezi Tenenboim,

Sarah Lechner,

Monika Demar,

Anette HabringMüller,

Christa Lanz,

Gunnar Rätsch,

Detlef Weigel

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.10.049

Subject(s) - biology , epistasis , genetics , gene , genome , immune receptor , allele , locus (genetics) , immune system

Intraspecific genetic incompatibilities prevent the assembly of specific alleles into single genotypes and influence genome- and species-wide patterns of sequence variation. A common incompatibility in plants is hybrid necrosis, characterized by autoimmune responses due to epistatic interactions between natural genetic variants. By systematically testing thousands of F1 hybrids of Arabidopsis thaliana strains, we identified a small number of incompatibility hot spots in the genome, often in regions densely populated by nucleotide-binding domain and leucine-rich repeat (NLR) immune receptor genes. In several cases, these immune receptor loci interact with each other, suggestive of conflict within the immune system. A particularly dangerous locus is a highly variable cluster of NLR genes, DM2, which causes multiple independent incompatibilities with genes that encode a range of biochemical functions, including NLRs. Our findings suggest that deleterious interactions of immune receptors limit the combinations of favorable disease resistance alleles accessible to plant genomes.

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