Accelerating HIV-1 Vaccine Efficacy Trials | Zendy

Dan H. Barouch | Zendy; Nelson L. Michael | Zendy

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Accelerating HIV-1 Vaccine Efficacy Trials

Author(s) -

Dan H. Barouch,

Nelson L. Michael

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.10.046

Subject(s) - hiv vaccine , vaccine efficacy , aids vaccines , clinical trial , virology , vaccine trial , human immunodeficiency virus (hiv) , immunology , biology , pre exposure prophylaxis , vaccination , medicine , intensive care medicine , men who have sex with men , bioinformatics , syphilis

Despite major advances in HIV-1 therapeutics and prevention strategies, the development of a safe and effective prophylactic HIV-1 vaccine will likely be critical for ending the global HIV-1 epidemic. Yet only four HIV-1 vaccine concepts have been tested for clinical efficacy over the past 30 years. In this Commentary, we describe key hurdles facing the HIV-1 vaccine development field and outline strategies to accelerate efficacy evaluation of novel HIV-1 vaccine candidates.

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