SnapShot: Mammalian Sirtuins | Zendy

Kristin A. Anderson | Zendy; Michelle Green | Zendy; Frank K. Huynh | Zendy; Gregory R. Wagner | Zendy; Matthew D. Hirschey | Zendy

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SnapShot: Mammalian Sirtuins

Author(s) -

Kristin A. Anderson,

Michelle Green,

Frank K. Huynh,

Gregory R. Wagner,

Matthew D. Hirschey

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.10.045

Subject(s) - biology , snapshot (computer storage) , nad+ kinase , microbiology and biotechnology , carcinogenesis , genetics , computational biology , biochemistry , gene , enzyme , computer science , operating system

The mammalian sirtuins have emerged as critical regulators of cellular stress resistance, energy metabolism, and tumorigenesis. In some contexts, they delay the onset of age-related diseases and promote a healthy lifespan. The seven mammalian sirtuins, SIRT1-7, share a highly conserved NAD+-binding catalytic core domain although they exhibit distinct expression patterns, catalytic activities, and biological functions. This SnapShot provides an overview of these properties, with an emphasis on their relevance to aging.

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