Open AccessStealing VEGF from Thy Neighbor
Author(s) -
Courtney K. Domigan,
M. Luisa IruelaArispe
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.10.008
Subject(s) - biology , vegf receptors , computational biology , genetics , microbiology and biotechnology , evolutionary biology , cancer research
The distribution and patterning of blood vessels is controlled by vascular endothelial growth factor (VEGF), which is precisely regulated throughout its life cycle. Okabe et al. show that VEGF is titrated away from the endothelium by adjacent neurons via endocytosis, regulating density and trajectory of blood vessels.
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