Mitochondria Tether Protein Trash to Rejuvenate Cellular Environments | Zendy

Axel Mogk | Zendy; Bernd Bukau | Zendy

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Mitochondria Tether Protein Trash to Rejuvenate Cellular Environments

Author(s) -

Axel Mogk,

Bernd Bukau

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.10.007

Subject(s) - biology , mitochondrion , yeast , microbiology and biotechnology , sorting , protein aggregation , saccharomyces cerevisiae , mechanism (biology) , genetics , philosophy , epistemology , computer science , programming language

Protein damage segregates asymmetrically in dividing yeast cells, rejuvenating daughters at the expense of mother cells. Zhou et al. now show that newly synthesized proteins are particularly prone to aggregation and describe a mechanism that tethers aggregated proteins to mitochondria. This association constrains aggregate mobility, effectively retaining and sorting toxic aggregates away from younger cells.

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