Open AccessMission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus
Author(s) -
Zulfiqar Ali Malik,
Ivar S. Stein,
Manuel F. Navedo,
Johannes Hell
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.09.023
Subject(s) - biology , calmodulin , nucleus , microbiology and biotechnology , biochemistry , enzyme
Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.
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