Open AccessMetabolism and the Other Fat: A Protocadherin in Mitochondria
Author(s) -
Nicholas E. Baker,
Andreas Jenny
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.08.039
Subject(s) - biology , protocadherin , mitochondrion , microbiology and biotechnology , metabolism , function (biology) , lipid metabolism , cell metabolism , cell , biochemistry , cadherin
The protocadherin Fat is known as a tumor suppressor regulating growth in Drosophila and for its conserved function during planar cell polarity establishment. McNeill and colleagues now identify an unsuspected role for a C-terminal proteolytic product of Fat in mitochondria: regulating the electron transport machinery and metabolism.
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