A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Jianwei Wang,1 Qian Sun,1,12 Yohei Morita,1,12 Hong Jiang,1 Alexander Groß,2 André Lechel,1 Kai Hildner,5 Luis Miguel Guachalla,1 Anne Gompf,1 Daniel Hartmann,1 Axel Schambach,6 Torsten Wuestefeld,7,8 Daniel Dauch,7,8 Hubert Schrezenmeier,3,11 Wolf-Karsten Hofmann,9 Hiromitsu Nakauchi,10 Zhenyu Ju,4 Hans A. Kestler,2 Lars Zender,7,8 and K. Lenhard Rudolph1,* 1Institute of Molecular Medicine and Max-Planck-Research Department of Stem Cell Aging 2Research Group Bioinformatics and Systems Biology, Institute of Neural Information Processing 3Institute for Clinical Transfusion Medicine and Immunogenetics University of Ulm, 89069 Ulm, Germany 4Institute of Aging Research, Hangzhou Normal University College of Medicine, Hangzhou, China 5Department of Medicine 1, Max Eder Research Group, University of Erlangen-Nürnberg, 91054 Erlangen, Germany 6Institute of Experimental Hematology, Hannover Medical School, 30625 Hannover, Germany 7Helmholtz Center for Infection Research, 38124 Braunschweig, Germany 8Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, 30625 Hannover, Germany 9Department of Hematology and Oncology, Mannheim University Hospital, 68167 Mannheim, Germany 10Guest Professorship University of Ulm, Germany, Centre for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, and Japan Science and Technology Agency, ERATO, Tokyo 108-8639, Japan 11German Red Cross Blood Transfusion Service Baden-Wurttemberg-Hessen, D-76530 Baden, Germany 12These authors contributed equally to this work *Correspondence: klrudolph@fli-leibniz.de DOI 10.1016/j.cell.2012.01.040 Open access under CC BY-NC-ND license.