Open AccessSending Mixed Messages for Cell Population Control
Author(s) -
Hyun Youk,
Wendell A. Lim
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.08.013
Subject(s) - autocrine signalling , paracrine signalling , biology , population , bistability , microbiology and biotechnology , cell , neuroscience , genetics , cell culture , receptor , physics , demography , quantum mechanics , sociology
Cells often receive signals to proliferate, but how population density is controlled is unclear. Hart et al. now show that a single secreted molecule that instructs both proliferation and death in T cells establishes a bistable response: the population is driven to either extinction or to a homeostatically defined density.
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