Open AccessBuilding a Temperature-Sensitive Ion Channel
Author(s) -
Ming-Feng Tsai,
Christopher Miller
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.08.008
Subject(s) - gating , biology , ion channel , channel (broadcasting) , ion , biophysics , materials science , biochemistry , electrical engineering , physics , engineering , receptor , quantum mechanics
The biophysical basis of temperature-sensitive ion channel gating has been a tough nut to crack. Chowdhury, et al. use a protein engineering approach to render a temperature-insensitive voltage-gated channel cold- or heat-responsive to reveal principles for temperature-gating and a plausible model for molecularly enabling this mode of environmental responsiveness.
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