Hippo Pathway Key to Ploidy Checkpoint | Zendy

Bin Zhao | Zendy; KunLiang Guan | Zendy

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Hippo Pathway Key to Ploidy Checkpoint

Author(s) -

Bin Zhao,

KunLiang Guan

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.07.041

Subject(s) - biology , ploidy , key (lock) , microbiology and biotechnology , hippo signaling pathway , g2 m dna damage checkpoint , protein serine threonine kinases , genetics , computational biology , cell cycle checkpoint , signal transduction , cell cycle , cancer , phosphorylation , gene , ecology , protein kinase a

Tetraploid cells generated by abnormal cell division are often arrested during the cell cycle or cleared by apoptosis. Evasion of these defense mechanisms leads to genomic instability and tumorigenesis. In this issue, Ganem et al. report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced cell-cycle arrest.

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