Open AccessChance, Destiny, and the Inner Workings of ClpXP
Author(s) -
Rick Russell,
Andreas Matouschek
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.07.009
Subject(s) - proteases , biology , protease , aaa proteins , biochemistry , enzyme , atpase , biophysics , microbiology and biotechnology
AAA+ proteases are responsible for protein degradation in all branches of life. Using single-molecule and ensemble assays, Cordova et al. investigate how the bacterial protease ClpXP steps through a substrate's polypeptide chain and construct a quantitative kinetic model that recapitulates the interplay between stochastic and deterministic behaviors of ClpXP.
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