SnapShot: Necroptosis | Zendy

Wen Zhou | Zendy; Junying Yuan | Zendy

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SnapShot: Necroptosis

Author(s) -

Wen Zhou,

Junying Yuan

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.06.041

Subject(s) - necroptosis , ripk1 , biology , microbiology and biotechnology , programmed cell death , extracellular , intracellular , kinase , snapshot (computer storage) , apoptosis , inflammation , signal transduction , necrosis , immunology , biochemistry , genetics , computer science , operating system

Regulated necrosis, termed necroptosis, is mediated by the kinase activity of RIPK1 and RIPK3. It has distinct cellular features that are different than apoptosis. Necroptosis can be triggered by extracellular stimuli known to activate inflammation and cell death and its intracellular signaling pathway involves necrosome formation and MLKL activation. Inhibition of necroptosis has been shown to mitigate pathology in numerous mouse models, providing potential strategies to treat human diseases.

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