A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase | Zendy

Vincent C. J. de Boer | Zendy; Sander M. Houten | Zendy

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A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase

Author(s) -

Vincent C. J. de Boer,

Sander M. Houten

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.06.018

Subject(s) - pyruvate dehydrogenase complex , biology , pyruvate decarboxylation , mitochondrion , pyruvate dehydrogenase kinase , biochemistry , branched chain alpha keto acid dehydrogenase complex , dihydrolipoyl transacetylase , pyruvate dehydrogenase phosphatase , acetylation , microbiology and biotechnology , dehydrogenase , enzyme , gene

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate into acetyl-CoA, a critical step in metabolism. Sutendra et al. now demonstrate that PDC can translocate from the mitochondria to the nucleus to provide acetyl-CoA necessary for histone acetylation, suggesting a new pathway for mitochondrial-nuclear communication.

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