Open AccessDesigner Proteins to Trigger Cell Death
Author(s) -
Wayne J. Fairbrother,
Avi Ashkenazi
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.06.010
Subject(s) - biology , microbiology and biotechnology , apoptosis , protein design , computational biology , in vitro , programmed cell death , virus , virology , protein structure , biochemistry
Efforts to generate biologically active proteins by de novo computational design have been limited to creating functional sites within pre-existing scaffolds. Procko et al. use an innovative computational design approach coupled with in-vitro-targeted evolution to produce a potent polypeptide inhibitor of a viral Bcl-2-like protein. This novel inhibitor triggers apoptosis of virus-infected cells.
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