The Angiotensin II Type 2 Receptor for Pain Control | Zendy

A.H. Jan Danser | Zendy; Praveen Anand | Zendy

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The Angiotensin II Type 2 Receptor for Pain Control

Author(s) -

A.H. Jan Danser,

Praveen Anand

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.05.030

Subject(s) - angiotensin ii receptor type 1 , angiotensin ii , receptor , vasoconstriction , biology , angiotensin receptor , endocrinology , renin–angiotensin system , pharmacology , medicine , biochemistry , blood pressure

All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. Yet, Ang II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20 years of research, remains largely unknown. In this issue, Marion et al. provide a new chapter to the AT2 receptor story.

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