Open AccessDelivering Three Punches to Knockout Intracellular Bacteria
Author(s) -
Émilie Narni-Mancinelli,
Éric Vivier
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.05.023
Subject(s) - biology , bacteria , cytotoxic t cell , intracellular , microbiology and biotechnology , granzyme , genetics , perforin , in vitro
Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.
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