Open AccessGetting a Grip on piRNA Cluster Transcription
Author(s) -
Alexandra Sapetschnig,
Eric A. Miska
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.05.022
Subject(s) - biology , piwi interacting rna , transposable element , genetics , drosophila melanogaster , genome , transcription (linguistics) , melanogaster , small rna , rna , gene , linguistics , philosophy
The generation of piRNAs from long primary transcripts requires specialized factors that distinguish these precursors from canonical RNA polymerase II transcripts. Mohn et al. and Zhang et al. provide evidence that in Drosophila melanogaster noncanonical transcription coupled with splicing inhibition differentiates piRNA precursors from mRNAs and ensures their correct processing.
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