Applying “Gold Standards” to In-Vitro-Derived Germ Cells | Zendy

Mary Ann Handel | Zendy; John J. Eppig | Zendy; John C. Schimenti | Zendy

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Applying “Gold Standards” to In-Vitro-Derived Germ Cells

Author(s) -

Mary Ann Handel,

John J. Eppig,

John C. Schimenti

Publication year - 2014

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2014.05.019

Subject(s) - biology , gametogenesis , germ , meiosis , in vitro , germ line development , germ plasm , microbiology and biotechnology , realization (probability) , stem cell , germ cell , genetics , embryo , gene , cryopreservation , statistics , mathematics

Germ cells are the ultimate stem cells, and reports of their in vitro derivation generate excitement due to potential applications in reproductive medicine. To date, there is no firm evidence that meiosis, the hallmark of gametogenesis, can be faithfully replicated outside of the gonad. We propose benchmarks for evaluating in vitro derivation of germ cells, facilitating realization of their potential.

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