Open AccessDie Another Day: A Painless Path to Longevity
Author(s) -
Sophie M. Steculorum,
Jens C. Brüning
Publication year - 2014
Publication title -
cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 26.304
H-Index - 776
eISSN - 1097-4172
pISSN - 0092-8674
DOI - 10.1016/j.cell.2014.05.013
Subject(s) - longevity , biology , trpv1 , bioinformatics , genetics , transient receptor potential channel , receptor
Riera et al. identify a neuroendocrine circuit that controls longevity and the age-dependent onset of metabolic decline via the pain-transducing channel TRPV1. Thus, pharmacological inhibition of TRPV1 may provide a new approach to treat not only metabolic disorders but also a broader range of age-related pathologies.
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